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Geldanamycin & Analogues

This page was prepared by the students of applied biochemistry, OpenUniversity.

1: Hadden MK, Lubbers DJ, Blagg BS. Geldanamycin, radicicol, and chimeric inhibitors of the Hsp90 N-terminal ATP binding site.
Curr Top Med Chem. 2006;6(11):1173-82. Review.
PMID: 16842154

2: Chiosis G, Caldas Lopes E, Solit D. Heat shock protein-90 inhibitors: a chronicle from geldanamycin to today's agents.
Curr Opin Investig Drugs. 2006 Jun;7(6):534-41. Review.
PMID: 16784024

3: Neckers L. Chaperoning oncogenes: Hsp90 as a target of geldanamycin.
Handb Exp Pharmacol. 2006;(172):259-77. Review. PMID: 16610363 

4: Miyata Y. Hsp90 inhibitor geldanamycin and its derivatives as novel cancer chemotherapeutic agents.
Curr Pharm Des. 2005;11(9):1131-8. Review.
PMID: 15853661 

5: Sausville EA. Geldanamycin analogs.
J Chemother. 2004 Nov;16 Suppl 4:68-9. Review.
PMID: 15688614 

6: Liao ZY, Zhen YS. [Advances in antitumor activity of the hsp90 inhibitor geldanamycin]
Yao Xue Xue Bao. 2001 Sep;36(9):716-20. Review. Chinese. No abstract available.
PMID: 12580116 

7: Blagosklonny MV. Hsp-90-associated oncoproteins: multiple targets of geldanamycin and its analogs.
Leukemia. 2002 Apr;16(4):455-62. Review.
PMID: 11960322 

8: Ochel HJ, Eichhorn K, Gademann G. Geldanamycin: the prototype of a class of antitumor drugs targeting the heat shock protein 90 family of molecular chaperones.
Cell Stress Chaperones. 2001 Apr;6(2):105-12. Review. No abstract available. Erratum in: Cell Stress Chaperones 2001 Jul;6(3):295.
PMID: 11599571 

9: Neckers L, Schulte TW, Mimnaugh E. Geldanamycin as a potential anti-cancer agent: its molecular target and biochemical activity.
Invest New Drugs. 1999;17(4):361-73. Review.
PMID: 10759403 

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